分子靶向抗HPV核心技术

该技术为高危HPV持续性感染的无创干预研究开辟了新的路径

基础研究表明，REBACIN相关活性成分能够选择性进入宫颈癌细胞核，

为阐明其靶向抑制高危HPV E6/E7致癌基因表达的作用机制提供了重要数据佐证。


自2000年立项以来，研发团队历经二十余年潜心研究与持续攻关，创新建立了该项核心技术，并获得多项中国发明专利授权。

迄今，相关研究成果已连续12届获准在国际乳头瘤病毒学术大会发表，其中4次被遴选做大会学术报告；

部分研究成果发表于《International Journal of Cancer（国际癌症杂志）》等国际学术期刊。

2000年立项

基础研究

分子靶向技术确立

国际学术认可

HPV E6/E7基因——无创干预的靶点

REBACIN研发团队精准锁定高危HPV持续性感染及相关生物学过程中的关键分子环节，

以抑制高危HPV E6/E7致癌基因表达、阻断病毒DNA复制为技术突破口，

创新建立分子靶向抗HPV核心技术，为高危HPV持续性感染的无创干预提供了新的技术支持。

2010年，在加拿大蒙特利尔召开的第26届国际HPV学术大会上，瑞贝生研发团队首次向国际学术界提出，

REBACIN的作用靶点为高危HPV E6/E7致癌基因，

较国际学术界于2017年达成E6/E7为治疗核心靶点的共识早了七年。

国际学术期刊论文
迄今为止，REBACIN研发团队已相继在国际学术期刊上发表多篇高影响因子论文。

REBACIN® as a noninvasive clinical intervention for high-risk human papillomavirus persistent infection

REBACIN® as a noninvasive clinical intervention for high-risk human papillomavirus persistent infection

REBACIN® as a noninvasive clinical intervention for high-risk human papillomavirus persistent infection
INT J CANCER.2019 NOV;145,2712-2719. IF：7.356
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Case Report: Noninvasive Clinical Intervention of REBACIN® on Histologic Regression of High Grade Cervical Intraepithelial Neoplasia

Case Report: Noninvasive Clinical Intervention of REBACIN® on Histologic Regression of High Grade Cervical Intraepithelial Neoplasia

Case Report: Noninvasive Clinical Intervention of REBACIN® on Histologic Regression of High Grade Cervical Intraepithelial Neoplasia
Front. Med., 2021 Jul 20;8:627355. IF：5.091
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REBACIN® is an optional intervention for persistent high‐risk human papillomavirus infection: A retrospective analysis of 364 patients

REBACIN® is an optional intervention for persistent high‐risk human papillomavirus infection: A retrospective analysis of 364 patients

REBACIN® is an optional intervention for persistent high‐risk human papillomavirus infection: A retrospective analysis of 364 patients
Int J Gynaecol Obstet. 2021 Jan;152(1):82-87. IF：3.561
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REBACIN® inhibits E6/E7 oncogenes in clearance of human papillomavirus infection

REBACIN® inhibits E6/E7 oncogenes in clearance of human papillomavirus infection

REBACIN® inhibits E6/E7 oncogenes in clearance of human papillomavirus infection
Front. Oncol.,2022 Dec 6:12:1047222. IF：5.738
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High-intensity focused ultrasound for patients with cervical intraepithelial neoplasia 2/3: A prospective one-arm study

High-intensity focused ultrasound for patients with cervical intraepithelial neoplasia 2/3: A prospective one-arm study

High-intensity focused ultrasound for patients with cervical intraepithelial neoplasia 2/3: A prospective one-arm study
Ultrasound Med Biol.2023 Jan;49(1):375-379. IF：3.694
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Effectiveness and safety of REBACIN as a non-invasive intervention for persistent high-risk human papillomavirus infection:A real-world prospective multicenter cohort study

Effectiveness and safety of REBACIN as a non-invasive intervention for persistent high-risk human papillomavirus infection:A real-world prospective multicenter cohort study

Effectiveness and safety of REBACIN as a non-invasive intervention for persistent high-risk human papillomavirus infection:A real-world prospective multicenter cohort study
Gynecol. Oncol.2023 Nov:178:8-13. IF：4.7
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REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective stud

REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective stud

REBACIN® can remove high-risk Human Papillomavirus (HPV) persistent infection efficiently as an effective non-invasive treatment: a multicenter prospective stud
World J Surg Oncol. 2026 Apr 25. IF：2.5
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国际HPV学术大会报告
部分研究成果自2010年起连续十二届在“国际HPV学术大会”上发表，其中四次被遴选在大会上作学术报告。

学术报告：

Pharmacokinetics of REBACIN Vaginal Delivery: Tissue Distribution, Nuclear Uptake,andOptimal Dosing for Enhanced Efficacy

届数：37时间：2025 10.23~10.26    |    地点：泰国-曼谷      page：239-240

发表论文：

Prospective Real-World Study of Non-Invasive Clinical Intervention with REBACIN® fortheElimination of HrHPV Persistent Infection and CIN1Histologic Regression

届数：36时间：2024 11.12~15    |    地点：英国-爱丁堡      page：459

发表论文：

Efficacy of REBACIN® Noninvasive Clinical Intervention in 3127 Patients with High-RiskPersistent HPV Infection

届数：35时间：2023 4.17~21    |    地点：美国-华盛顿     page：719-720

发表论文：

Efficacy of REBACIN and Recombinant Human Interferon Alpha-2B on the Non-invasiveTreatment of Clearing High-Risk Human Papilloma Virus Persistent Infection

届数：34时间：2021 11.15~19    |    地点：加拿大-多伦多       page：200

学术报告：

Real-World Evidence on Clinical Effect of REBACIN® as A Non-Invasive Intervention for High-Risk Human Papillomavirus Persistent Infection

发表论文：

A Noninvasive Clinical Intervention of REBACIN® for High-Risk Human Papillomavirus Persistent Infection

届数：33时间：2020.7.20~24    |    地点：西班牙-巴塞罗那     page：111、972

学术报告：

Efficacy of REBACIN® Combination with ALA-PDT on the Treatment of HPV Induced Intraepithelial Neoplasian Regression of Cervical

发表论文：

Potent Efficacy of REBACIN® on Regression of Cervical Intraepithelial Neoplasia

届数：32时间：2018.10.2~6    |    地点：澳大利亚-悉尼     page：1180

发表论文：

Efficacy and Safety of REBACIN® as Non-invasive Intervention Therapy for Sustained High Risk HPV (hrHPV) Infections

届数：31时间：2017.2.28~3.4    |    地点：南非-开普敦     page：426

发表论文：

Effectiveness of REBACIN® for Early Intervention on High Risk HPV Infection

届数：30时间：2015.9.17~21    |    地点：葡萄牙-里斯本     page：688

发表论文：

Efficacy of REBACIN® on Intervention of Sustained High Risk HPV (hrHPV) Infections

届数：29时间：2014.8.20~25    |    地点：美国-西雅图     page：198

发表论文：

Effects of REBACIN® in Treatment of Cervical Intraepithelial Neoplasia (CIN) Following LEEP Procedure

届数：28时间：2012.11.30~12.6    |    地点：波多黎各-圣胡安     page：225

学术报告：

Effect of REBACIN® in Treatment of High Risk HPV Infection

届数：27时间：2011.9.17~22    |    地点：德国-柏林     page：164

发表论文：

Efficient suppression of E6 and E7 gene expression and the growth of HPV16/HPV18-induced tumor in mouse model by REBACIN®, a novel antiviral factor

届数：26时间：2010.7.3~8    |    地点：加拿大-蒙特利尔     page：270